Top 5 Best Dog Digestive Enzymes in 2024

If your dog has been experiencing any digestion-related issues, or if you’re just looking for a product that will promote overall gut health, you may be thinking about starting your dog on a digestive enzyme. This can help your dog break down the food they eat, which will make it easier to digest.

There are a variety of types and brands of enzymes that are available, so we have conducted a review of five of the best options on the market this year. So let’s get into it!

Our Top 5 List

Last update on 2024-05-10 at 06:53 / Affiliate links / Images from Amazon Product Advertising API

1. Zesty Paws Multivitamin & Digestive Enzymes

Zesty Paws Multivitamin Treats for Dogs - Glucosamine Chondroitin for Joint Support + Digestive Enzymes & Probiotics - Grain Free Dog Vitamin for Skin & Coat + Immune Health - Chicken Flavor - 90ct

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Zesty Paws is a daily multivitamin that will provide your dog with a variety of benefits. The digestive enzymes contained in this chewable vitamin, along with the five-strain probiotic and niacin, will help promote a healthy digestive system. The enzymes can be especially helpful is your dog has been having issues with constipation, diarrhea, bloating, or gas.

In addition to the enzymes in this product, there are also a variety vitamins, minerals, and nutrients. The Kaneka Q10 will help your dog’s cardiovascular system and the A, C, and E vitamins will help improve their immune system.

The chews also contain OptiMSM, Glucosamine HCL, and Chondroitin Sulfate to keep your dog’s hips and joints healthy and strong. Finally, they also contain cod liver fish oil and vitamin E. These ingredients provide an anti-itch feature and can help alleviate dry skin while promoting a healthy and shiny coat.


  • The enzymes in the chews can help your dog if they have been having trouble with diarrhea or constipation.
  • The vitamins are chewable, so they’ll be easy for your dog to take.
  • Each chew contains vitamins and minerals that will also help promote a healthy heart, joints, skin, and coat.


  • These cause some (very few) dogs to have an upset stomach.

2. PetVitalityPRO Probiotics for Dogs

PetVitalityPRO Probiotics for Dogs with Natural Digestive Enzymes ● 4 Bill CFUs/2 Soft Chews ● Dog Diarrhea Upset Stomach Yeast Gas Bad Breath Immunity Allergies Skin Itching Hot Spots ● 60 Count

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Another quality product with digestive enzymes to help your dog is the PetVitalityPRO Probiotic. This formula can help keep your dog’s gut healthy. They can also help provide relief for problems such as constipation, diarrhea, loose stool, gas, upset stomach, bloating, vomiting, malabsorption, bad breath, and yeast infections.

If your dog has recently been on an antibiotic or receive a steroid treatment, this product can help get their gut health back where it should be. The enzymes in this product can also help your dog absorb more important nutrients from their food. Giving your dog this daily probiotic can also help improve allergies, promote a healthy coat and skin, help clear up urinary tract infections, and provide relief for hot spots.


  • This product is masked as a delicious treat that your dog will enjoy eating.
  • It helps to keep your dog’s gut healthy and can help provide relief for a variety of issues from diarrhea to yeast infections to vomiting.
  • This option is made in The United States in an FDA registered facility. It is GMP and SQF certified.


  • If you have a large dog who weighs more than 60 pounds, you’ll need to give them four soft chews each day.
  • You’ll have to purchase a great quantity of treats, which can get expensive.

3. Nusentia Probiotic Miracle Dog Probiotics for Dogs

NUSENTIA Probiotic Miracle Dog Probiotics for Dogs (Up to 360 Servings)

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The Nusentia Probiotic Miracle is designed to help dogs who are facing a range of digestive issues. You can help your dog get the relief they deserve if they have been having trouble with yeast, itching, allergies, gut problems, loose stool, diarrhea, constipation, or bad breath.

This product is recommended by many veterinarians. It is made without the use of rice, maltodextrin, gluten, dairy, soy, or fillers. This option is also non-GMO and does not contain any artificial flavorings or animal byproducts.

Each scoop contains more than a billion CFU of probiotics. Since there are 360 scoops in each jar, this is also a more economical option than some other products.


  • This product can help relieve digestive issues such as diarrhea, constipation, bad breath, and gas.
  • There are no fillers, artificial flavors, gluten, or dairy in this product.
  • There are more than a billion CFU of probiotics in each scoop.


  • The powder may dry up in the container if it is not properly sealed or protected against moisture.

4. Nusentia Enzymes for Dogs & Cats

NUSENTIA Enzymes for Dogs & Cats - Enzyme Miracle - Systemic & Digestive Enzyme Formula - Powder - 364 Servings - Vegetarian

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Your dog will benefit from the 11 types of plant based systemic and enzymes contained in the Nusentia Enzymes. Each day, you’ll need to mix one scoop with your dog’s food. Doing so can help them avoid or find relief for digestive issues including indigestion, yeast, build-up of toxins, and pancreatic issues that may be developing.

Each scoop of this product includes Bromelain which is an anti-inflammatory enzyme. It also contains a proteolytic enzyme which will help with your dog’s digestion and overall health. The powder has no flavor, so it will be easy to add over your dog’s food without them objecting.

There are no byproducts, dairy, wheat, soy, eggs, or artificial flavoring in this product. It does not contain any animal ingredients, so if your dog is on a vegetarian diet, you can still use this product.


  • The enzymes will help promote healthy digestion and can improve the overall health of your dog.
  • You can also use this product with cats.
  • The manufacturer offers a 100% money back guarantee if you are not satisfied with your purchase.


  • The scoop for this product often gets ‘lost’ under the powder, leading to a mess when you have to dig it out each day.

5. NaturVet Enzymes, Probiotics & Prebiotics

NaturVet - Digestive Enzymes - Plus Probiotics & Prebiotics - Helps Support Diet Change & A Healthy Digestive Tract - for Dogs & Cats - 4 oz Powder

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If you are looking for a product that contains enzymes, probiotics, and prebiotics, consider the NaturVet formula. The enzymes found in this product are designed to help your dog effective break down the foods they eat. This can lead to increased utilization of the nutrients found in foods and can help provide relief for digestion-related issues.

The probiotic in this product offers your dog a viable naturally occurring microorganism. This can help improve the health of their digestive tract.

If you are planning to transition your dog onto a new food, adding this problem can help prevent digestion or stomach issues that are often associated with making a change. This product is also great to use for dogs that have a more sensitive stomach or are having issues with flatulence.


  • This option contains enzymes, probiotics, and prebiotics.
  • When transitioning your dog to a new food, this product can help prevent stomach issues.
  • If you have cats, you can also use this product with them.


  • You will have to find your own scoop or spoon to use with this product as a scoop is not provided.


Zesty Paws Multivitamin & Enzyme Treats








Test-Dog Approval



  • Effective
  • Our dogs love it
  • Multivitamin, minerals, and enzymes in one
  • Easy to chew


  • We haven't encountered any cons.

All five of the enzyme supplements we reviewed would be a good addition to your dog’s daily routine. However, after completing our reviews, we most strongly recommend Zesty Paws.

Zesty Paws is a multivitamin chew that you’ll find easy to get your dog to take each day. It contains digestive enzymes, niacin, and a probiotic that are designed to help your dog if they have been having trouble with diarrhea, gas, constipation, or bloating.

This daily chew also includes other vitamins and minerals that will help your dog to develop a healthy cardiovascular system, keep their hips and joints healthy, and help them with any dry skin issues they may be experiencing.

We think you’ll see a noticeable difference in your dog when you start them on Zesty Paws. Place your order today; the sooner you get them started, the sooner you’ll start seeing the benefits.

Buying Guide

Adding a digestive enzyme to your dog’s diet can help them get relief from stomach issues, including diarrhea, constipation, gas, bad breath, and indigestion. Since every enzyme is a little different, you will want to closely compare the different products you are considering to help you select the one that will deliver the most benefits for your dog.

Problems Addressed

First, be sure to read the list of benefits associated with taking each enzyme you are considering. Be sure to confirm that any issues your dog may be experiencing will be addressed by the product you select.

Other Supplements or Vitamins Included

Many enzymes are included as part of a supplement. Some of these supplements may be multivitamins, while others are probiotics. Consider the health benefits associated with each option to help you choose the right combination for your dog’s specific needs.

Product Type

Next, you should think about the different product types. Some enzymes are found in a daily chew or treat, while others may come in a powdered form that you will scoop over your pet’s food each day. Both types can be equally effective, so you will want to choose the option that you think your dog will be most likely to readily eat.

Serving Size/Value

When comparing prices of enzymes, you can’t simply look at the total cost or even the number of scoops or treats in a container. Different products will have different serving sizes, and this will likely vary based on your dog’s weight.

To help you determine the daily cost associated with a product, you can first determine the number of servings your dog will get out of the container based on their weight. You can then divide the total cost of the product by the number of servings. This will let you know how much each serving will cost you.

Veterinarian Recommendations

Finally, it is always a good idea to check with your veterinarian before making a change in your dog’s diet. You can get their recommendations for the product type that they think will deliver the greatest benefits to your dog’s health.


How do enzymes help dogs?

Digestive enzymes are designed to help your dog break down their foods more easily and effectively. This will help ensure that your dog’s body is able to absorb more of the nutrients found in the foods they eat.

These enzymes can also help if your dog has been experiencing any digestion-related issues. For example, if your dog has been having trouble is constipation, diarrhea, gas, or indigestion, giving them a daily dose of a digestive enzyme could help them find relief for these issues.

How frequently should I give my dog such enzymes?

You may want to consult with your veterinarian and check the specific directions on the product you choose, but most enzymes are designed to be given once every day.

What serving should I give my dog?

The serving size will vary based on the specific product you choose. Digestive enzymes dosages are typically determined by your dog’s weight, so the dose received by one dog will likely be different from what another dog gets. Most enzymes are either treats/chews or a powder you will sprinkle over your dog’s food. The exact number of treats or scoops of powder they will receive will vary with different brands.

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